A new study (Powers et al., 2026) just confirmed something that should change the way we talk about diet and health—not just heart health, but brain health, metabolism, and, if you’ve been following this site, endocannabinoid health, too. When you look at red‑blood‑cell fatty acids, you’re not seeing a niche…
Category: Endocannabinoid System (ECS)
Endocannabinoid System (ECS)
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Bariatric Surgery Progressively Recouples the eCBome
How Bariatric Surgery Recouples the Endocannabinoidome For years, obesity has been framed as a simple problem of “too many calories in, not enough out.” The endocannabinoidome (eCBome) tells a different story. In severe obesity, the lipid‑signaling network that should help regulate appetite, energy balance and metabolic health is present, but…
Endocannabinoid System (ECS)
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Liraglutide, 2‑AG and the Microbiome: A New Gut–Brain Pathway for Antidepressant Effects
From metabolic drug to mood modulator A new paper in Cell Host & Microbe has just delivered one of the most compelling mechanistic stories yet for how the endocannabinoid system (ECS) links metabolic drugs, the gut microbiome, and mood regulation. The study shows that the antidepressant effects of the GLP‑1…
Endocannabinoid System (ECS)
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The Mouse That Can’t Get Fat — and What It Reveals About Your Endocannabinoid System
There is a mouse that refuses to follow the script. Feed it a high-fat Western diet for sixteen months and it stays leaner, its gut stays tighter, its blood stays cleaner, and its cells age more slowly. Not because of a drug. Because of one change: the balance of fats…
Endocannabinoid System (ECS)
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ECS Literacy in Medicine: Why It Makes Better Doctors
What happens to clinical reasoning when a physician understands the endocannabinoid system? Seven conditions, two kinds of doctors, and the reasoning gap that a better curriculum could close.
Endocannabinoid System (ECS)
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How Poor Diet and Insulin Spikes Disrupt the Endocannabinoid System and Drive Fatty Liver
Scientists have identified a new mechanism linking everyday diet to endocannabinoid system (ECS) dysfunction: normal post‑meal insulin spikes can increase CB1 receptors in the liver by about 50% by slowing their lysosomal recycling. Together with an omega‑6‑heavy fat intake, this amplifies diet‑driven steatosis and helps explain how common foods drive fatty liver disease.
Endocannabinoid System (ECS)
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Why an Omega-3 Trial for Anxiety Accidentally Proved Something Far More Interesting About Your Endocannabinoid System
A new randomised, double-blind, placebo-controlled trial published in the Journal of Affective Disorders set out to test whether omega-3 supplementation improves stress, anxiety, depression, sleep quality, and memory in people with severe psychological distress (Azhar et al., 2025). The trial was conducted on a Saudi population, was reasonably well-designed, and produced striking…
Endocannabinoid System (ECS)
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Your ECS Under Load: Regular Cannabis, Exercise, and a Blunted Runner’s High
Your ECS under load, not at rest Most cannabis conversations live in the acute space: “How does it feel when I’m high?” or in vague long‑term boxes like “motivation” or “psychosis risk.” Almost nobody asks the more mechanistic question that actually matters for resilience: What does your endocannabinoid system do…
Critical analysis
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The Missing System: How a Major 2026 Review on Cardiometabolic Health Ignores the Endocannabinoid System
Last August, I wrote about a troubling pattern in inflammation research: brilliant scientists studying arachidonic acid metabolism while remaining “blissfully unaware that half the arachidonic acid story exists in a parallel research universe.” I documented how eicosanoid researchers and endocannabinoid scientists study the same substrate, same concentration ranges, same tissues—yet publish in…
Endocannabinoid System (ECS)
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The Medical Cannabis Paradox: How Tolerance Threatens Long-Term Therapeutic Success
A follow-up to “CB1 Availability as a Non-Invasive Biomarker: Bridging Endocannabinoid System Dysfunction and Therapeutic Monitoring“ The Emerging Evidence: Tolerance is Real and Quantifiable A recent study published in Frontiers in Pharmacology (2025) provided the first systematic measurement of how tolerance accumulates during medical cannabis treatment (Stith et al., 2025). Using real-world…