Tag: Systems biology

Illustration of endocannabinoid signalling through CB1 receptors in the brain, showing how synaptic adaptation supports learning and behavioural adaptation.

How the Endocannabinoid System Helps the Brain Adapt and Learn

Posted on August 17, 2026August 17, 2026 By Stefan Broselid

The Endocannabinoid System and the Biology of Learning: How Endocannabinoids Help the Brain Adapt Why one-shot learning matters for survival Imagine touching a hot surface for the first time. The experience lasts only a moment, but the lesson can last a lifetime. The brain does not need repeated exposure to…

Endocannabinoid System (ECS)

Jigsaw puzzle of fatty liver disease with a new insulin→CB1 piece connecting insulin spikes to hepatic CB1 and steatosis, leaving some gaps for unknown mechanisms.

How Poor Diet and Insulin Spikes Disrupt the Endocannabinoid System and Drive Fatty Liver

Posted on May 21, 2026May 21, 2026 By Stefan Broselid

Scientists have identified a new mechanism linking everyday diet to endocannabinoid system (ECS) dysfunction: normal post‑meal insulin spikes can increase CB1 receptors in the liver by about 50% by slowing their lysosomal recycling. Together with an omega‑6‑heavy fat intake, this amplifies diet‑driven steatosis and helps explain how common foods drive fatty liver disease.