Tag: Receptor trafficking

Scientific illustration showing THC activation of the CB1 receptor and the Gq/11–PLC–PKC–NEDD4L pathway leading to CB1 ubiquitination, proteasomal degradation and cannabinoid tolerance, with ECS.education branding.

How Repeated THC Exposure Can Reduce CB1 Receptors

Posted on September 14, 2026September 14, 2026 By Stefan Broselid

A new PNAS study identifies a previously underappreciated Gq/11–PLC–PKC–NEDD4L pathway that marks CB1 receptors for proteasomal degradation. The findings help explain how repeated THC exposure can reduce receptor availability and contribute to cannabinoid tolerance.

Announcements

Scientific illustration showing a CB1 receptor in the cell membrane, with metabolic state influencing receptor stability and lysosomal degradation. Dietary fat composition and carbohydrate-driven insulin responses are shown as upstream factors, with liver, adipose tissue, skeletal muscle, brain, and heart representing insulin-sensitive tissues.

Open letter to CB1 researchers

Posted on September 3, 2026September 3, 2026 By Stefan Broselid

An open letter inviting researchers to investigate whether metabolic state influences CB1 receptor stability, trafficking and degradation across insulin-sensitive tissues, and whether this represents a broader principle of endocannabinoid system regulation.