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ECS is Physiology

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Endocannabinoid Science Education
Endocannabinoid Science Education

ECS is Physiology

Tag: lipid signaling

Announcements Scientific illustration showing a CB1 receptor in the cell membrane, with metabolic state influencing receptor stability and lysosomal degradation. Dietary fat composition and carbohydrate-driven insulin responses are shown as upstream factors, with liver, adipose tissue, skeletal muscle, brain, and heart representing insulin-sensitive tissues.

Open letter to CB1 researchers

Posted on September 3, 2026September 3, 2026 By Stefan Broselid

An open letter inviting researchers to investigate whether metabolic state influences CB1 receptor stability, trafficking and degradation across insulin-sensitive tissues, and whether this represents a broader principle of endocannabinoid system regulation.

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Commentary Conceptual illustration showing membrane fatty-acid state as a baseline biological condition, followed by an endurance running challenge and distinct arachidonate/endocannabinoid responses involving AEA, arachidonic acid and 2-AG. A red blood cell and phospholipid membrane represent longer-term fatty-acid status, a runner represents prolonged exercise, and non-quantitative signal traces represent the time-dependent ECS response. ECS.education logo appears in the upper right.

The missing membrane layer in a new marathon endocannabinoid study

Posted on September 3, 2026September 3, 2026 By Stefan Broselid

A new BMC Medicine study shows that marathon running triggers distinct temporal changes in anandamide, 2-AG and arachidonic acid. The missing piece may be the runners’ membrane fatty-acid state before exercise.

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Endocannabinoid System (ECS) Metaphor graphic comparing diet to a hybrid car: omega‑6 and omega‑3 “power lines” route to the engine, while a floor unit symbolizes microbiome energy integration.

Beyond the ECS: Why you absolutely need a balanced diet

Posted on October 8, 2025 By Stefan Broselid

Your body produces its own cannabis-like molecules. Right now, as you read this, your cells are manufacturing compounds that interact with the same receptors that THC targets. But here’s what most people don’t realize: this system extends far beyond what we traditionally call the “endocannabinoid system”, and the food on…

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