A new PNAS study identifies a previously underappreciated Gq/11–PLC–PKC–NEDD4L pathway that marks CB1 receptors for proteasomal degradation. The findings help explain how repeated THC exposure can reduce receptor availability and contribute to cannabinoid tolerance.
Tag: cannabis tolerance
Endocannabinoid System (ECS)
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Tolerance changes the economics of medical cannabis
A New York study found that 49% of surveyed medical cannabis patients could not afford enough cannabis to manage their symptoms. This article examines a missing variable in the affordability debate: whether chronic high-THC exposure, tolerance and CB1 adaptation may increase the amount of cannabis required for sustained therapeutic effect.
Endocannabinoid System (ECS)
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Your ECS Under Load: Regular Cannabis, Exercise, and a Blunted Runner’s High
Your ECS under load, not at rest Most cannabis conversations live in the acute space: “How does it feel when I’m high?” or in vague long‑term boxes like “motivation” or “psychosis risk.” Almost nobody asks the more mechanistic question that actually matters for resilience: What does your endocannabinoid system do…