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ECS is Physiology

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Endocannabinoid Science Education
Endocannabinoid Science Education

ECS is Physiology

Endocannabinoid System (ECS) Satirical cartoon depicting a biochemical plateau where molecules cluster in a safety zone while warning signs point to an arachidonic acid canyon and inflammation zone below—illustrating the hidden dangers of excess linoleic acid in modern diets.

The Biochemical Plateau: Rethinking Linoleic Acid and Heart Health

Posted on October 23, 2025 By Stefan Broselid

The Linoleic Acid Paradox: Protection or Peril? For decades, linoleic acid has enjoyed a privileged place in nutritional policy. It is the cornerstone of “heart-healthy” messaging, the molecular mascot of seed oils, and the quiet passenger in countless processed foods. But beneath this reputation lies a paradox: the very molecule…

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Commentary Split-screen comparison of enzyme inhibitor effects: Day 1 shows dramatic metabolic improvements (53% insulin drop, 23% reduced food intake) when DAGL and NAPE-PLD are blocked, but Day 7 reveals complete failure as arachidonic acid substrate reroutes to inflammatory COX/LOX pathways, causing weight rebound, inflammation, and glucose dysfunction

The Enzyme Inhibitor Paradox: Why Anti-Obesity Drugs Keep Failing

Posted on October 19, 2025October 19, 2025 By Stefan Broselid

A new study just proved something remarkable: researchers found a way to slash insulin levels by 53% in just two hours. Food intake dropped 23%. Body weight fell within 24 hours. The pharmaceutical industry should be celebrating. Except there’s a problem. By day seven, it stopped working. Completely. The mice…

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Endocannabinoid System (ECS) Metaphor graphic comparing diet to a hybrid car: omega‑6 and omega‑3 “power lines” route to the engine, while a floor unit symbolizes microbiome energy integration.

Beyond the ECS: Why you absolutely need a balanced diet

Posted on October 8, 2025 By Stefan Broselid

Your body produces its own cannabis-like molecules. Right now, as you read this, your cells are manufacturing compounds that interact with the same receptors that THC targets. But here’s what most people don’t realize: this system extends far beyond what we traditionally call the “endocannabinoid system”, and the food on…

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Commentary Two-panel faculty meeting scene; left, a male professor in a white coat asks ‘Shouldn’t we teach the ECS? I know it’s about a lot more than cannabis’; right, a sweating administrator looks anxious and repeats ‘Shouldn’t we teach the ECS…’; bottom banner reads ‘Let’s start asking the uncomfortable questions!’ with the ECS.education logo and ‘Join the movement!’

Let’s Start Asking the Uncomfortable Questions about the ECS

Posted on September 30, 2025September 30, 2025 By Stefan Broselid

A half-century of medical curricula has overlooked one of human physiology’s master regulators—the endocannabinoid system (ECS). But the conversation is shifting. In faculty rooms across the world, one question is changing the temperature: “Shouldn’t we teach the ECS?” Educational omissions translate directly into gaps in patient care. Closing both is imperative. Every revolution…

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Endocannabinoid System (ECS) Soybean oil and linoleic acid tipping gut lipid balance: diagram showing linoleic acid driving arachidonic acid toward eicosanoids while endocannabinoids decrease, with a bottle of soybean oil and soybeans.

Soybean oil, linoleic acid, and the gut ECS

Posted on September 19, 2025September 19, 2025 By Stefan Broselid

A recent study titled ‘Diet high in linoleic acid dysregulates the intestinal endocannabinoid system and increases susceptibility to colitis in Mice‘ shows that eating a lot of linoleic acid from soybean oil changes lipid chemistry in the gut in a way that weakens the protective endocannabinoid system and strengthens inflammatory…

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Commentary Header graphic with a crowned emperor alongside keywords linking endocannabinoids to the arachidonic acid map: AEA, 2‑AG, COX‑2, MAGL, FAAH, PLA2, 5‑LOX, CYP450, prostamides, leukotrienes, lipoxins, EETs, HETEs.”

The Emperor’s New Pathways: Endocannabinoids on the Arachidonic Acid Map

Posted on September 11, 2025September 11, 2025 By Stefan Broselid

Most NAFLD/MASLD reviews draw a neat AA trident—COX, LOX, CYP—while omitting the endocannabinoid system, even though AEA and 2‑AG are made on demand by NAPE‑PLD and DAGLα/β and rapidly hydrolyzed by FAAH and MAGL back to AA, continuously shuttling substrate between eCBs and eicosanoids in inflamed liver. A new 2025…

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Announcements Illustration announcing “Peer‑review passed” for a publication in the journal “I JCMCS: International Journal of Clinical & Medical Case Studies,” with a facing page reading “Bridging the gap: Integrating the endocannabinoid system into medical education” beside cartoon figures of a lab‑coated clinician holding a clipboard and a person at a laptop, green molecular icons and a cannabis leaf in the background, and a footer line stating “The ECS.education community has a milestone to celebrate.”

From Preprint to Peer Review: ECS.education Paper Accepted in IJCMCS

Posted on August 29, 2025August 29, 2025 By Stefan Broselid

The ECS.education community has a milestone to celebrate: our manuscript, “Bridging the gap: Integrating the endocannabinoid system into medical education,” has passed independent, double‑blind peer review and is now published in the International Journal of Clinical & Medical Case Studies (IJCMCS). Built around three cornerstone ECS.education analyses, the paper consolidates…

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Commentary llustration showing rows of scientists in lab coats and blindfolds standing in a tunnel filled with laboratory equipment, mathematical formulas, and the words “fatty acids” and “anti-inflammatory” written on the walls. Light shines at the end of the tunnel, symbolizing limited vision or awareness. On the right, the text reads “How inflammation research ignores the endocannabinoid system (ECS): When scientific tunnel vision becomes institutional blindness.” The ECS.education logo appears at the bottom right.

How Scientific Tunnel Vision in Inflammation Research Ignores the Endocannabinoid System (ECS)

Posted on August 19, 2025 By Stefan Broselid

When scientific tunnel vision becomes institutional blindness Lessons from history’s scientific blind spots Science has a troubling habit of missing the forest for the trees. For decades, gastroenterologists dismissed the idea that bacteria could cause stomach ulcers—until Barry Marshall proved Helicobacter pylori was the culprit by infecting himself. Geologists ridiculed…

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Endocannabinoid System (ECS) Illustration showing the link between obesity and dysfunction in the endocannabinoid system (ECS). The image includes a silhouette of an overweight person, a fingerprint, a brain with a cannabis leaf symbol, and a chemical structure with the text 'ECS.education'

Obesity’s metabolic fingerprint is characterised by ECS Dysfunction!

Posted on August 2, 2025 By Stefan Broselid

Obesity isn’t just about extra weight—it imprints a unique metabolic fingerprint deep within your body. New research reveals that this signature is marked by endocannabinoid system (ECS) dysfunction, driven by dietary fat balance and energy surplus. Learn how what you eat tunes your ECS, shapes your health risks, and why fixing the “input side” of nutrition could help fade the metabolic fingerprint of obesity.

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Critical analysis Illustration depicting a mother breastfeeding her infant, surrounded by icons of BMI, omega-3 and omega-6 fatty acids, a fish, green leaves, and a brain diagram, with the caption 'Maternal Obesity Disrupts Breast Milk PUFA Balance' from ECS.education

Maternal Obesity Disrupts Breast Milk PUFA Balance: New Insights into ECS Programming for Infants

Posted on July 23, 2025July 23, 2025 By Stefan Broselid

Let’s dive right in. In my earlier posts on ECS.education, we’ve talked about how maternal adiposity shapes breast milk’s endocannabinoid system (ECS) and influences infant health. The May 23 piece on ‘The Adiposity Filter: How Maternal Body Fat Reshapes Milk PUFAs for Your Baby’s ECS‘ highlighted shifts in endocannabinoid profiles…

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