Tag: membrane lipids

The missing membrane layer in a new marathon endocannabinoid study

Posted on September 3, 2026September 3, 2026 By Stefan Broselid

A new BMC Medicine study shows that marathon running triggers distinct temporal changes in anandamide, 2-AG and arachidonic acid. The missing piece may be the runners’ membrane fatty-acid state before exercise.

Endocannabinoid System (ECS)

Three-panel scientific illustration comparing endocannabinoid system function across three dietary states. Left panel: High omega-6 diet showing excess CB1 receptor stress and 2-AG/AEA production (omega-6:omega-3 ratio 20:1). Center panel: Optimized substrates with balanced membrane composition supporting multiple endocannabinoid types and receptor function. Right panel: High omega-3 diet showing activated TRPV1/TRPA1 ion channels, PPARα activation, and anti-inflammatory endocannabinoid production (omega-3:omega-6 ratio 4:1). Bottom tagline: Substrate availability dictates endocannabinoid system function.

2025 in ECS Research: The Year the Substrate-Driven ECS Model Came of Age

Posted on December 28, 2025December 28, 2025 By Stefan Broselid

Endocannabinoid system substrate—specifically membrane fatty acid composition—is the primary determinant of CB1 receptor function, not genetics or receptor density. For years, I’ve been making the case that endocannabinoid system function is not primarily about receptor density or genetic variants, it’s about substrate availability. The composition of fatty acids in cell…