Tag: insulin resistance

Scientific illustration showing metabolic dysfunction in visceral adipose tissue increasing 2-AG and anandamide production, while hyperinsulinemia is associated with increased CB1 receptor stability. Both pathways converge on a central CB1 receptor embedded in a cell membrane.

When Metabolic Dysfunction Acts on Both Sides of CB1 Signalling

Posted on October 6, 2026October 6, 2026 By Stefan Broselid

A new Diabetologia study shows that insulin-resistant visceral adipose tissue overproduces 2-AG and anandamide, while recent work suggests insulin can also increase CB1 receptor stability. Together, these findings raise a testable question: can metabolic dysfunction amplify CB1 signalling by increasing both endogenous ligand production and receptor abundance?

Nutrition Science

Too Much Omega-6? New Link Shows Linoleic Acid Directly Flips a Master Metabolic Switch

Posted on May 5, 2025May 5, 2025 By Stefan Broselid

Discover how dietary linoleic acid (LA), a major omega-6 fat, directly activates the master metabolic switch mTORC1 through a newly found pathway involving FABP5. Explore the implications for Metabolic Syndrome, potential interactions with the endocannabinoid system (ECS), and what this means for understanding modern diets.