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Endocannabinoid Science Education
Endocannabinoid Science Education

ECS is Physiology

Tag: gut–brain axis

Endocannabinoid System (ECS)

Liraglutide, 2‑AG and the Microbiome: A New Gut–Brain Pathway for Antidepressant Effects

Posted on June 17, 2026 By Stefan Broselid

From metabolic drug to mood modulator A new paper in Cell Host & Microbe has just delivered one of the most compelling mechanistic stories yet for how the endocannabinoid system (ECS) links metabolic drugs, the gut microbiome, and mood regulation. The study shows that the antidepressant effects of the GLP‑1…

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