Tag: DAGL

A white paracetamol tablet emits glowing signals into an interconnected network of lipid-like molecules, cell membranes and neurons, shifting from warm orange inflammatory activity to cool blue-green signalling against a dark background.

Paracetamol, 2-AG and CB1: The ECS Story Just Got More Complicated

Posted on September 9, 2026September 8, 2026 By Stefan Broselid

New mouse research reveals that paracetamol’s pain-relieving effects depend on CB1 receptors and the enzymes DAGL and MAGL, while reshaping prostaglandin and wider lipid signalling.

Endocannabinoid System (ECS)

Paracetamol as an Analgesic DAGL Inhibitor – Mechanism Confirmed by Jesus et al. 2025 Preprint

Paracetamol Confirmed as a Direct Analgesic DAGL Inhibitor: New Preprint Evidence

Posted on June 4, 2025June 4, 2025 By Stefan Broselid

Important Note: This blog post discusses findings from a recent scientific preprint, meaning the research has not yet been formally peer-reviewed. Preprints allow for rapid dissemination of findings, but results should be interpreted cautiously until confirmed by peer-reviewed publication. Recently, we reported on a surprising new way that paracetamol (also known…

Pharmacology

Acetaminophen (APAP) & the ECS: A Surprising New Twist in How Tylenol Really Works

Posted on May 19, 2025May 19, 2025 By Stefan Broselid

New research upends our understanding of how acetaminophen (paracetamol) provides pain relief via the endocannabinoid system. Discover how it directly inhibits DAGLα, reducing 2-AG levels – a surprising twist on conventional ECS wisdom. Explore the implications for future drug development.