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ECS is Physiology

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Endocannabinoid Science Education
Endocannabinoid Science Education

ECS is Physiology

Endocannabinoid System (ECS) Illustration of an overweight person sitting next to a stylized neuron and molecular structures, visually representing the concept that obesity rewires the endocannabinoid system.

Obesity Rewires Your Endocannabinoid System (ECS): How Fat, Liver, Heart & Brain Are Transformed

Posted on June 17, 2025 By Stefan Broselid

Obesity is more than excess fat—it’s a disorder of endocannabinoid system (ECS) dysfunction. Explore how obesity rewires CB1 signaling in fat, liver, heart, and brain, driving chronic disease.

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Endocannabinoid System (ECS) Paracetamol as an Analgesic DAGL Inhibitor – Mechanism Confirmed by Jesus et al. 2025 Preprint

Paracetamol Confirmed as a Direct Analgesic DAGL Inhibitor: New Preprint Evidence

Posted on June 4, 2025June 4, 2025 By Stefan Broselid

Important Note: This blog post discusses findings from a recent scientific preprint, meaning the research has not yet been formally peer-reviewed. Preprints allow for rapid dissemination of findings, but results should be interpreted cautiously until confirmed by peer-reviewed publication. Recently, we reported on a surprising new way that paracetamol (also known…

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Nutrition Science Conceptual image illustrating how maternal adiposity influences breast milk PUFA levels (like DHA & AA) and impacts infant endocannabinoid system (ECS) development.

The Adiposity Filter: How Maternal Body Fat Reshapes Milk PUFAs for Your Baby’s ECS

Posted on May 23, 2025May 23, 2025 By Stefan Broselid

At ECS.education, we’ve previously delved into how maternal metabolism and milk composition program infant development, the profound impact of maternal diet on the endocannabinoidome and infant health, and the links between ECS dysfunction, conditions like autism, and metabolic syndrome. Today, we explore compelling new research that adds another crucial layer to this understanding:…

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Endocannabinoid System (ECS) Chemical structure of Agmatine overlaid on a micrograph, with text: The Agmatine-ECS Connection - New Hope for ASD by Boosting 2-AG and Calming the Brain.

The Agmatine-ECS-ASD Connection: New Hope for ASD by Boosting 2-AG and Calming the Brain

Posted on May 22, 2025May 22, 2025 By Stefan Broselid

Explore groundbreaking research on agmatine’s connection to the endocannabinoid system (ECS) in Autism (ASD). Discover how it may boost 2-AG, calm brain inflammation, and offer new hope for understanding and potentially supporting ASD.

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Pharmacology

Acetaminophen (APAP) & the ECS: A Surprising New Twist in How Tylenol Really Works

Posted on May 19, 2025May 19, 2025 By Stefan Broselid

New research upends our understanding of how acetaminophen (paracetamol) provides pain relief via the endocannabinoid system. Discover how it directly inhibits DAGLα, reducing 2-AG levels – a surprising twist on conventional ECS wisdom. Explore the implications for future drug development.

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Commentary

Seeing is Believing: New Tech Reveals How The Endocannabinoid System Works in Real-Time

Posted on May 6, 2025 By Stefan Broselid

A paradigm-shifting review in Neuron (Malhotra et al., 2025) highlights how new technologies allow scientists to visualize endocannabinoid (ECS) dynamics in real-time in behaving animals. This post breaks down the key breakthroughs, including the central role of 2-AG in rapid signaling, its precision, its function in memory and seizures, and the implications for healthcare professionals and medical cannabis.

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Nutrition Science

Too Much Omega-6? New Link Shows Linoleic Acid Directly Flips a Master Metabolic Switch

Posted on May 5, 2025May 5, 2025 By Stefan Broselid

Discover how dietary linoleic acid (LA), a major omega-6 fat, directly activates the master metabolic switch mTORC1 through a newly found pathway involving FABP5. Explore the implications for Metabolic Syndrome, potential interactions with the endocannabinoid system (ECS), and what this means for understanding modern diets.

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Nutrition Science

Maternal Obesity Reshapes Breast Milk’s Endocannabinoid Landscape – A Missing Link in Metabolic Inheritance

Posted on May 2, 2025May 2, 2025 By Stefan Broselid

Discover how maternal obesity and GDM reshape breast milk’s endocannabinoid profile, linking mother’s metabolic health to infant development via the ECS. Explore the crucial role of omega-6/3 balance, recent human evidence on growth impacts, complexities from animal models, and the urgent case for prioritizing maternal omega-3 intake.

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Critical analysis

Omega-6, Mortality, and Your ECS: Unpacking the Latest UK Biobank Bombshell

Posted on April 27, 2025 By Stefan Broselid

A major UK Biobank study found higher plasma linoleic acid (LA) linked to lower mortality, seemingly contradicting concerns about high dietary omega-6 driving ECS dysfunction. This post unpacks the findings, distinguishing between plasma snapshots and tissue arachidonic acid (AA) realities, and explains why the omega-6/omega-3 balance and ECS perspective remain crucial for understanding metabolic health.

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Critical analysis

The Invisible Puppeteer in Seed Oil Research

Posted on April 9, 2025April 9, 2025 By Stefan Broselid

Let’s cut through the noise: Petersen et al.’s recent industry-funded narrative review, published in Nutrition Today, employs selective framing—shifting focus away from the central regulator of metabolism, the endocannabinoid system (ECS). This 600-million-year-old conductor of hunger, fat storage, and inflammation is fueled by linoleic acid (LA), yet the manuscript acts…

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