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Endocannabinoid Science Education
Endocannabinoid Science Education

ECS is Physiology

Tag: Paracetamol

Autism Spectrum DIsorder (ASD) Decoding Autism: Lipidomic Dysregulation Meets ECS Dysfunction - Illustration showing a person looking in mirror reflecting labels of lipidomic dysregulation and ECS dysfunction, symbolizing two aspects of the same condition

Lipidomic Markers Predict Autism Through ECS Dysfunction

Posted on October 29, 2025 By Stefan Broselid

Autism research has long struggled with a fundamental question: why do so many disparate findings (maternal nutrition, inflammation, mitochondrial dysfunction, environmental exposures) all seem to correlate with ASD risk? A new systematic review may have inadvertently provided the unifying answer, though the authors themselves haven’t yet connected the dots. A…

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Endocannabinoid System (ECS) Paracetamol as an Analgesic DAGL Inhibitor – Mechanism Confirmed by Jesus et al. 2025 Preprint

Paracetamol Confirmed as a Direct Analgesic DAGL Inhibitor: New Preprint Evidence

Posted on June 4, 2025June 4, 2025 By Stefan Broselid

Important Note: This blog post discusses findings from a recent scientific preprint, meaning the research has not yet been formally peer-reviewed. Preprints allow for rapid dissemination of findings, but results should be interpreted cautiously until confirmed by peer-reviewed publication. Recently, we reported on a surprising new way that paracetamol (also known…

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Pharmacology

Acetaminophen (APAP) & the ECS: A Surprising New Twist in How Tylenol Really Works

Posted on May 19, 2025May 19, 2025 By Stefan Broselid

New research upends our understanding of how acetaminophen (paracetamol) provides pain relief via the endocannabinoid system. Discover how it directly inhibits DAGLα, reducing 2-AG levels – a surprising twist on conventional ECS wisdom. Explore the implications for future drug development.

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