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Endocannabinoid Science Education
Endocannabinoid Science Education

ECS is Physiology

Tag: cannabis tolerance management

Endocannabinoid System (ECS) Minimalist illustration showing a central dial without markings, positioned over a faint brain outline. The dial balances two opposing arrows labeled ‘Symptom Control’ and ‘Cognitive Function,’ with a hand hovering uncertainly above it, symbolizing the trade-off between therapeutic efficacy and cognitive safety in medical cannabis use without knowledge of CB1 receptor availability.

The Medical Cannabis Paradox: How Tolerance Threatens Long-Term Therapeutic Success

Posted on January 24, 2026January 24, 2026 By Stefan Broselid

A follow-up to “CB1 Availability as a Non-Invasive Biomarker: Bridging Endocannabinoid System Dysfunction and Therapeutic Monitoring“ The Emerging Evidence: Tolerance is Real and Quantifiable A recent study published in Frontiers in Pharmacology (2025) provided the first systematic measurement of how tolerance accumulates during medical cannabis treatment (Stith et al., 2025). Using real-world…

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