Most NAFLD/MASLD reviews draw a neat AA trident—COX, LOX, CYP—while omitting the endocannabinoid system, even though AEA and 2‑AG are made on demand by NAPE‑PLD and DAGLα/β and rapidly hydrolyzed by FAAH and MAGL back to AA, continuously shuttling substrate between eCBs and eicosanoids in inflamed liver. A new 2025…
Category: Critical analysis

Maternal Obesity Disrupts Breast Milk PUFA Balance: New Insights into ECS Programming for Infants
Let’s dive right in. In my earlier posts on ECS.education, we’ve talked about how maternal adiposity shapes breast milk’s endocannabinoid system (ECS) and influences infant health. The May 23 piece on ‘The Adiposity Filter: How Maternal Body Fat Reshapes Milk PUFAs for Your Baby’s ECS‘ highlighted shifts in endocannabinoid profiles…

Beyond the Buzz: Cannabis Heart Risks vs. Diet-Driven ECS Overload
Introduction: Beyond the Buzz – A Flawed Focus on Cannabis Recent headlines have lit up with warnings about cannabis and heart health, fueled by a systematic review showing links to increased risks of strokes, heart attacks, and cardiovascular death. It’s easy to get caught up in the alarm. After all, who doesn’t want to protect their ticker? But here’s where our reasoning goes off track:…

Omega-6, Mortality, and Your ECS: Unpacking the Latest UK Biobank Bombshell
A major UK Biobank study found higher plasma linoleic acid (LA) linked to lower mortality, seemingly contradicting concerns about high dietary omega-6 driving ECS dysfunction. This post unpacks the findings, distinguishing between plasma snapshots and tissue arachidonic acid (AA) realities, and explains why the omega-6/omega-3 balance and ECS perspective remain crucial for understanding metabolic health.

The Invisible Puppeteer in Seed Oil Research
Let’s cut through the noise: Petersen et al.’s recent industry-funded narrative review, published in Nutrition Today, employs selective framing—shifting focus away from the central regulator of metabolism, the endocannabinoid system (ECS). This 600-million-year-old conductor of hunger, fat storage, and inflammation is fueled by linoleic acid (LA), yet the manuscript acts…

The Silent Saboteur: How Modern Diets Hijack Your Body’s Master Regulator (While Science Looks Away)
Discover how ‘heart-healthy’ seed oils may hijack your body’s ancient metabolic regulator—the endocannabinoid system—driving obesity, mental health crises, and neurodevelopmental disorders. Explore why 50 years of nutrition research ignores this critical connection.

The Hidden Epidemic: ECS Dysfunction at the Crossroads of Autism and Obesity
Explore how modern diets rich in omega-6 fatty acids may disrupt the endocannabinoid system (ECS), linking autism spectrum disorder (ASD) and metabolic syndrome through shared mechanisms of inflammation, neurodevelopment, and metabolism.

Challenging the Daily Mail: The Science Behind Medical Cannabis for ADHD and Menopause
Professor Sir Robin Murray’s claim that ‘cannabis has the same effect as drinking a pint’ for psychological conditions, published in the Daily Mail, oversimplifies the science behind medical cannabis. This commentary explores the evidence supporting cannabis as a therapeutic option for ADHD and menopause while addressing misconceptions about its efficacy and safety.

Beyond Omission: Integrating ECS into Medical Education – A Blueprint for Change
Executive Summary An analysis of the Physiological Society’s 2020 “Physiological Objectives for Medical Students” curriculum guide reveals a critical gap: the complete omission of the Endocannabinoid System (ECS). This official curriculum guidance document, which establishes core physiological knowledge for new doctors, overlooks a system fundamental to maintaining homeostasis across multiple…