Endocannabinoid Science Education | Stefan Broselid | Activity

Stefan Broselid wrote a new post

Mon, 16 Mar 2026 08:18:44 +0000

Why an Omega-3 Trial for Anxiety Accidentally Proved Something Far More Interesting About Your Endocannabinoid System A new randomised, double-blind, placebo-controlled trial published in the Journal of Affective Disorders set out to test whether omega-3 supplementation i […]

Stefan Broselid wrote a new post

Mon, 02 Mar 2026 15:27:20 +0000

Your ECS Under Load: Regular Cannabis, Exercise, and a Blunted Runner’s High Your ECS under load, not at rest Most cannabis conversations live in the acute space: “How does it feel when I’m high?” or in vague long‑term boxes l […]

Stefan Broselid wrote a new post

Mon, 02 Feb 2026 18:23:45 +0000

The Missing System: How a Major 2026 Review on Cardiometabolic Health Ignores the Endocannabinoid System Last August, I wrote about a troubling pattern in inflammation research: brilliant scientists studying arachidonic acid metabolism while remaining […]

Stefan Broselid wrote a new post

Sat, 24 Jan 2026 16:03:11 +0000

The Medical Cannabis Paradox: How Tolerance Threatens Long-Term Therapeutic Success A follow-up to “CB1 Availability as a Non-Invasive Biomarker: Bridging Endocannabinoid System Dysfunction and Therapeutic Monitoring” The Emerging […]

Stefan Broselid wrote a new post

Fri, 16 Jan 2026 12:41:28 +0000

The New US Dietary Guidelines: Eat to Support Your ECS This article explains how the endocannabinoid system is shaped by diet, especially omega‑6 and omega‑3 fats. The 2025–2030 US Dietary Guidelines proces […]

Stefan Broselid wrote a new post

Thu, 15 Jan 2026 15:05:21 +0000

A Future Where CB1 Is Visible: CB1 Availability Biomarkers A Future Where CB1 Is Visible The CB1 Number On Your Phone Right now, the endocannabinoid system is mostly guesswork in the clinic. People come in […]

Stefan Broselid wrote a new post

Sun, 28 Dec 2025 11:06:53 +0000

2025 in ECS Research: The Year the Substrate-Driven ECS Model Came of Age Endocannabinoid system substrate—specifically membrane fatty acid composition—is the primary determinant of CB1 receptor function, not genetics or rec […]

Stefan Broselid wrote a new post

Thu, 18 Dec 2025 11:08:22 +0000

JAMA, Medical Cannabis and the Endocannabinoid Blind Spot There is a saying in science: Absence of evidence is not evidence of absence. But in the case of the recent JAMA review on the therapeutic use of cannabis, I […]

Stefan Broselid wrote a new post

Wed, 10 Dec 2025 14:56:25 +0000

ECS and Exercise: The Invisible Architecture of Fitness The body keeps secrets in its blood. On a Tuesday morning in late 2024, 491 men and women stepped onto treadmills and cycle ergometers across several […]

Stefan Broselid wrote a new post

Thu, 04 Dec 2025 08:47:59 +0000

When Percentages Lie: Rethinking Omega‑6 (LA & AA) Risk Biomarkers and Endocannabinoid Substrates The blind spot in fatty acid epidemiology Since the 1960s, most circulating fatty acid data have been reported as “percent of total” rather than as abs […]

Stefan Broselid wrote a new post

Mon, 17 Nov 2025 15:48:40 +0000

The Swedish Sin: When Evidence-Based Medicine Meets Bureaucratic Barriers The Swedish Sin Here’s a thing that’s been bothering me for months now. Sweden claims to have medical cannabis. We tell patients it’s “legal.” We point to […]

Stefan Broselid wrote a new post

Wed, 05 Nov 2025 17:33:04 +0000

How Diet and Exercise Modulate the Endocannabinoid System New Evidence for the Substrate-Driven Model I came across a fascinating recent study […]

Stefan Broselid wrote a new post

Wed, 29 Oct 2025 05:45:17 +0000

Lipidomic Markers Predict Autism Through ECS Dysfunction Autism research has long struggled with a fundamental question: why do so many disparate findings (maternal nutrition, inflammation, mitochondrial […]

Stefan Broselid wrote a new post

Thu, 23 Oct 2025 11:44:19 +0000

The Biochemical Plateau: Rethinking Linoleic Acid and Heart Health The Linoleic Acid Paradox: Protection or Peril? For decades, linoleic acid has enjoyed a privileged place in nutritional policy. It is the cornerstone of […]

Stefan Broselid wrote a new post

Sun, 19 Oct 2025 17:01:42 +0000

The Enzyme Inhibitor Paradox: Why Anti-Obesity Drugs Keep Failing A new study just proved something remarkable: researchers found a way to slash insulin levels by 53% in just two hours. Food intake dropped 23%. Body weight […]

Stefan Broselid wrote a new post

Wed, 08 Oct 2025 09:36:38 +0000

Beyond the ECS: Why you absolutely need a balanced diet Your body produces its own cannabis-like molecules. Right now, as you read this, your cells are manufacturing compounds that interact with the same receptors […]

Stefan Broselid wrote a new post

Tue, 30 Sep 2025 13:54:43 +0000

Let’s Start Asking the Uncomfortable Questions about the ECS A half-century of medical curricula has overlooked one of human physiology’s master regulators—the endocannabinoid system (ECS). But the conversation is s […]

Stefan Broselid wrote a new post

Fri, 19 Sep 2025 14:03:54 +0000

Soybean oil, linoleic acid, and the gut ECS A recent study titled ‘Diet high in linoleic acid dysregulates the intestinal endocannabinoid system and increases susceptibility to colitis in Mice’ shows […]

Stefan Broselid wrote a new post

Thu, 11 Sep 2025 12:57:48 +0000

The Emperor’s New Pathways: Endocannabinoids on the Arachidonic Acid Map Most NAFLD/MASLD reviews draw a neat AA trident—COX, LOX, CYP—while omitting the endocannabinoid system, even though AEA and 2‑AG are made on demand by NAPE‑ […]

Stefan Broselid wrote a new post

Fri, 29 Aug 2025 12:59:16 +0000

From Preprint to Peer Review: ECS.education Paper Accepted in IJCMCS The ECS.education community has a milestone to celebrate: our manuscript, “Bridging the gap: Integrating the endocannabinoid system into medical e […]

Stefan Broselid wrote a new post

Tue, 19 Aug 2025 09:03:16 +0000

How Scientific Tunnel Vision in Inflammation Research Ignores the Endocannabinoid System (ECS) When scientific tunnel vision becomes institutional blindness Lessons from history’s scientific blind spots Science has a troubling habit of missing t […]

Stefan Broselid wrote a new post

Sat, 02 Aug 2025 13:27:51 +0000

Obesity's metabolic fingerprint is characterised by ECS Dysfunction! Think of your body as a living journal, where each entry is made up of the molecules you absorb and the energy you store. Although obesity is often d […]

Stefan Broselid started the topic Alcohol Acutely Reduces 2-AG levels in the forum Infographics and educational content

Mon, 28 Jul 2025 13:06:37 +0000

Stefan Broselid wrote a new post

Wed, 23 Jul 2025 08:50:07 +0000

Maternal Obesity Disrupts Breast Milk PUFA Balance: New Insights into ECS Programming for Infants Let’s dive right in. In my earlier posts on ECS.education, we’ve talked about how maternal adiposity shapes breast milk’s endocannabinoid system (ECS) and […]

Stefan Broselid wrote a new post

Wed, 23 Jul 2025 05:03:47 +0000

The Endocannabinoid System: Dietary Precursor-Driven ECS & Medical Education Gap The Misunderstood Master Regulator The endocannabinoid system (ECS) is often considered the “cannabis system,” but this label ignores its true—and far b […]

Stefan Broselid wrote a new post

Sat, 19 Jul 2025 15:16:53 +0000

Beyond the Buzz: Cannabis Heart Risks vs. Diet-Driven ECS Overload Introduction: Beyond the Buzz – A Flawed Focus on Cannabis Recent headlines have lit up with warnings about cannabis and heart health, fueled by a sys […]

Stefan Broselid started the topic CNR1 expression During Lifespan in the forum Infographics and educational content

Fri, 11 Jul 2025 07:58:36 +0000

https://ecs.education/wp-content/uploads/2025/07/CNR1Lifespan-scaled.jpg

Stefan Broselid wrote a new post

Mon, 07 Jul 2025 14:09:20 +0000

An Update on Endogenous 2-AG Signaling: New Mechanisms and Cellular Integration Introduction: The Evolution of an Idea When I first began my career in molecular pharmacology, the endocannabinoid system (ECS) quickly became a sourc […]

Stefan Broselid wrote a new post

Tue, 17 Jun 2025 12:09:24 +0000

Obesity Rewires Your Endocannabinoid System (ECS): How Fat, Liver, Heart & Brain Are Transformed When we talk about obesity, most people focus on excess fat. But a closer look at the science—and the figure below—reveals a deeper story: obesity is a dis […]

Stefan Broselid wrote a new post

Wed, 04 Jun 2025 14:19:45 +0000

Paracetamol Confirmed as a Direct Analgesic DAGL Inhibitor: New Preprint Evidence Important Note: This blog post discusses findings from a recent scientific preprint, meaning the research has not yet been formally peer-reviewed. Preprints […]

Stefan Broselid wrote a new post

Fri, 23 May 2025 13:55:53 +0000

The Adiposity Filter: How Maternal Body Fat Reshapes Milk PUFAs for Your Baby's ECS At ECS.education, we’ve previously delved into how maternal metabolism and milk composition program infant development, the profound impact of maternal d […]

Stefan Broselid wrote a new post

Thu, 22 May 2025 15:34:00 +0000

The Agmatine-ECS-ASD Connection: New Hope for ASD by Boosting 2-AG and Calming the Brain The quest to understand and treat complex brain disorders has led researchers down many paths. Now, an often-overlooked endogenous molecule, agmatine, is s […]

Stefan Broselid wrote a new post

Mon, 19 May 2025 12:09:44 +0000

Acetaminophen (APAP) & the ECS: A Surprising New Twist in How Tylenol Really Works In a previous post, “Paracetamol: The Endocannabinoid System Connection,” we delved into the intriguing ways acetaminophen (paracetamol) interfaces with o […]

Stefan Broselid wrote a new post

Tue, 06 May 2025 14:15:37 +0000

Seeing is Believing: New Tech Reveals How The Endocannabinoid System Works in Real-Time For decades, scientists have known our bodies have an “inner cannabis system” – the endocannabinoid system (ECS). It’s a master regulator involved in eve […]

Stefan Broselid wrote a new post

Mon, 05 May 2025 12:52:34 +0000

Too Much Omega-6? New Link Shows Linoleic Acid Directly Flips a Master Metabolic Switch Our bodies have intricate systems for sensing the nutrients we eat. A key player is a protein complex called mTORC1, which acts like a master switch inside […]

Stefan Broselid wrote a new post

Fri, 02 May 2025 11:42:18 +0000

Maternal Obesity Reshapes Breast Milk's Endocannabinoid Landscape – A Missing Link in Metabolic Inheritance A growing body of research has established that the endocannabinoid system (ECS) is dysregulated in obesity. In both human and animal studies, obesity is […]

Stefan Broselid wrote a new post

Sun, 27 Apr 2025 14:44:08 +0000

Omega-6, Mortality, and Your ECS: Unpacking the Latest UK Biobank Bombshell Continuing our series on Omega-6, the Endocannabinoid System, Seed Oils, and Metabolic Health In our last two posts [1, 2], we explored how the massive […]

Stefan Broselid wrote a new post

Wed, 09 Apr 2025 10:07:55 +0000

The Invisible Puppeteer in Seed Oil Research Let’s cut through the noise: Petersen et al.’s recent industry-funded narrative review, published in Nutrition Today, employs selective fra […]

Stefan Broselid wrote a new post

Tue, 08 Apr 2025 10:33:57 +0000

The Silent Saboteur: How Modern Diets Hijack Your Body’s Master Regulator (While Science Looks Away) You’re doing everything “right”—drizzling seed oils on salads, avoiding butter, following every dietary guideline—yet you’re trapped in a cycle of craving […]

Stefan Broselid wrote a new post

Wed, 12 Mar 2025 10:28:11 +0000

Dietary Omega-3/6 Balance: New Research Links Fatty Acid Ratios to Chronic Disease and Longevity Recent high-quality research provides compelling evidence for what many nutrition scientists have long suspected: the balance between omega-6 and omega-3 […]

Stefan Broselid wrote a new post

Fri, 28 Feb 2025 12:19:41 +0000

The Hidden Epidemic: ECS Dysfunction at the Crossroads of Autism and Obesity The Dual Epidemics Over the past 60 years, two seemingly unrelated conditions—Metabolic Syndrome and Autism Spectrum Disorder (ASD)—have surged in para […]

Stefan Broselid wrote a new post

Tue, 04 Feb 2025 18:10:02 +0000

A Paradigm-Shift in Endocannabinoidome Pharmacology – Adenylyl Cyclases as Lipid-Sensing Receptors Introduction: A New Role for Dietary Fats For decades, fats have been categorized as either “good” or “bad,” depending on their effects on […]

Stefan Broselid wrote a new post

Sat, 01 Feb 2025 11:59:51 +0000

The Missing Link in Medicine: How the Endocannabinoid System (ECS) could Revolutionize HealthcareWhy isn’t the endocannabinoid system (ECS) taught in medical schools? This ancient system regulates hunger, pain, metabolism, and immunity—and it’s under […]

Stefan Broselid wrote a new post

Mon, 27 Jan 2025 11:31:41 +0000

Challenging the Daily Mail: The Science Behind Medical Cannabis for ADHD and Menopause The Daily Mail’s recent article on medical cannabis clinics raises important questions about the role of cannabis in treating conditions like ADHD and m […]

Stefan Broselid wrote a new post

Thu, 19 Dec 2024 10:31:57 +0000

Dietary Fats – More Than Just Sources of Energy For decades, dietary fats have been misunderstood, often labeled as “bad” without considering their true complexity. But fats are not just a source of […]

Stefan Broselid replied to the topic Omega fats and the ECS in the forum Infographics and educational content

Wed, 18 Dec 2024 15:36:58 +0000

Stefan Broselid wrote a new post

Fri, 13 Dec 2024 10:49:27 +0000

Understanding Medical Cannabis and the ECS The endocannabinoid system (ECS) is one of the most important physiological systems in our body, regulating processes like mood, sleep, and pain. Yet, many […]

Stefan Broselid wrote a new post

Tue, 26 Nov 2024 12:35:17 +0000

Beyond Omission: Integrating ECS into Medical Education – A Blueprint for Change Executive Summary An analysis of the Physiological Society’s 2020 “Physiological Objectives for Medical Students” curriculum guide reveals a critical gap: […]

Stefan Broselid wrote a new post

Sun, 24 Nov 2024 13:13:12 +0000

The Great Medical Education Blind Spot: How 2,470 ECS Publications Go Ignored A peculiar disconnect exists in modern medicine. While 2,470 peer-reviewed publications document the Endocannabinoid System’s (ECS) crucial role in […]

Stefan Broselid wrote a new post

Tue, 19 Nov 2024 15:55:01 +0000

Beyond Calories: How Dietary Fats Shape Our Cellular Architecture and Determine our Health Unlike carbohydrates, which simply provide energy, dietary fats play a far more sophisticated role in human physiology. The fatty acids we consume literally […]