Endocannabinoid Science Education | Stefan Broselid | Activity

Stefan Broselid wrote a new post

Mon, 14 Sep 2026 09:20:50 +0000

How Repeated THC Exposure Can Reduce CB1 Receptors A new PNAS study identifies the molecular pathway linking sustained cannabinoid exposure to CB1 receptor degradation and tolerance Cannabis tolerance is […]

Stefan Broselid wrote a new post

Mon, 14 Sep 2026 06:16:58 +0000

The Endocannabinoid System Is No Longer the Limiting Factor? Almost. Policy and stigma have delayed cannabinoid medicine, but the clinical translation of ECS physiology remains incomplete A new review published i […]

Stefan Broselid wrote a new post

Wed, 09 Sep 2026 08:00:00 +0000

Paracetamol, 2-AG and CB1: The ECS Story Just Got More Complicated Paracetamol—acetaminophen, or APAP—remains one of the most familiar medicines in the world. It is in medicine cabinets, hospital formularies and cli […]

Stefan Broselid wrote a new post

Mon, 07 Sep 2026 07:07:04 +0000

Tolerance changes the economics of medical cannabis A pharmacological look at affordability, tolerance, CB1 adaptation and the very different THC exposure patterns emerging in medical cannabis. A new study […]

Stefan Broselid wrote a new post

Thu, 03 Sep 2026 16:56:02 +0000

Open letter to CB1 researchers This open letter was first reported by CannaReporter on September 2, 2026. The full scientific statement and current list of signatories are published here […]

Stefan Broselid wrote a new post

Thu, 03 Sep 2026 07:05:21 +0000

The missing membrane layer in a new marathon endocannabinoid study What the new study found about the endocannabinoid system and endurance […]

Stefan Broselid wrote a new post

Mon, 17 Aug 2026 06:19:39 +0000

How the Endocannabinoid System Helps the Brain Adapt and Learn The Endocannabinoid System and the Biology of Learning: How Endocannabinoids Help the Brain Adapt Why one-shot learning matters for survival Imagine […]

Stefan Broselid wrote a new post

Thu, 25 Jun 2026 12:29:11 +0000

The Western Diet Has a Hot ECS — but Clinical Medicine Isn't Paying Attention A new study (Powers et al., 2026) just confirmed something that should change the way we talk about diet and health—not just heart health, but brain h […]

Stefan Broselid wrote a new post

Thu, 18 Jun 2026 10:00:00 +0000

Bariatric Surgery Progressively Recouples the eCBome How Bariatric Surgery Recouples the Endocannabinoidome For years, obesity has been framed as a simple problem of “too many calories in, not enough o […]

Stefan Broselid wrote a new post

Wed, 17 Jun 2026 12:08:29 +0000

Liraglutide, 2‑AG and the Microbiome: A New Gut–Brain Pathway for Antidepressant Effects From metabolic drug to mood modulator A new paper in Cell Host & Microbe has just delivered one of the most compelling mechanistic stories yet for how the […]

Stefan Broselid wrote a new post

Sun, 14 Jun 2026 18:49:49 +0000

The Mouse That Can't Get Fat — and What It Reveals About Your Endocannabinoid System There is a mouse that refuses to follow the script. Feed it a high-fat Western diet for sixteen months and it stays leaner, its gut stays tighter, its blood […]

Stefan Broselid wrote a new post

Tue, 26 May 2026 12:22:08 +0000

ECS Literacy in Medicine: Why It Makes Better Doctors Medical education has always faced a tension between depth and breadth. There is only so much room in a curriculum, and something always gets cut. For […]

Stefan Broselid wrote a new post

Thu, 21 May 2026 07:48:31 +0000

How Poor Diet and Insulin Spikes Disrupt the Endocannabinoid System and Drive Fatty Liver Scientists have just added an important new piece to the diet–ECS story, and it makes our everyday food choices look even more consequential for l […]

Stefan Broselid wrote a new post

Wed, 06 May 2026 13:21:48 +0000

Low plasma linoleic acid is a marker of high FADS activity – not a license to drink seed oil A new UK Biobank paper on omega‑6 and adiposity just landed, and if you only read the abstract, you’d think the story was simple: higher linoleic acid (LA […]

Stefan Broselid wrote a new post

Mon, 16 Mar 2026 08:18:44 +0000

Why an Omega-3 Trial for Anxiety Accidentally Proved Something Far More Interesting About Your Endocannabinoid System A new randomised, double-blind, placebo-controlled trial published in the Journal of Affective Disorders set out to test whether omega-3 supplementation i […]

Stefan Broselid wrote a new post

Mon, 02 Mar 2026 15:27:20 +0000

Your ECS Under Load: Regular Cannabis, Exercise, and a Blunted Runner’s High Your ECS under load, not at rest Most cannabis conversations live in the acute space: “How does it feel when I’m high?” or in vague long‑term boxes l […]

Stefan Broselid wrote a new post

Mon, 02 Feb 2026 18:23:45 +0000

The Missing System: How a Major 2026 Review on Cardiometabolic Health Ignores the Endocannabinoid System Last August, I wrote about a troubling pattern in inflammation research: brilliant scientists studying arachidonic acid metabolism while remaining […]

Stefan Broselid wrote a new post

Sat, 24 Jan 2026 16:03:11 +0000

The Medical Cannabis Paradox: How Tolerance Threatens Long-Term Therapeutic Success A follow-up to “CB1 Availability as a Non-Invasive Biomarker: Bridging Endocannabinoid System Dysfunction and Therapeutic Monitoring” The Emerging […]

Stefan Broselid wrote a new post

Fri, 16 Jan 2026 12:41:28 +0000

The New US Dietary Guidelines: Eat to Support Your ECS This article explains how the endocannabinoid system is shaped by diet, especially omega‑6 and omega‑3 fats. The 2025–2030 US Dietary Guidelines proces […]

Stefan Broselid wrote a new post

Thu, 15 Jan 2026 15:05:21 +0000

A Future Where CB1 Is Visible: CB1 Availability Biomarkers A Future Where CB1 Is Visible The CB1 Number On Your Phone Right now, the endocannabinoid system is mostly guesswork in the clinic. People come in […]

Stefan Broselid wrote a new post

Sun, 28 Dec 2025 11:06:53 +0000

2025 in ECS Research: The Year the Substrate-Driven ECS Model Came of Age Endocannabinoid system substrate—specifically membrane fatty acid composition—is the primary determinant of CB1 receptor function, not genetics or rec […]

Stefan Broselid wrote a new post

Thu, 18 Dec 2025 11:08:22 +0000

JAMA, Medical Cannabis and the Endocannabinoid Blind Spot There is a saying in science: Absence of evidence is not evidence of absence. But in the case of the recent JAMA review on the therapeutic use of cannabis, I […]

Stefan Broselid wrote a new post

Wed, 10 Dec 2025 14:56:25 +0000

ECS and Exercise: The Invisible Architecture of Fitness The body keeps secrets in its blood. On a Tuesday morning in late 2024, 491 men and women stepped onto treadmills and cycle ergometers across several […]

Stefan Broselid wrote a new post

Thu, 04 Dec 2025 08:47:59 +0000

When Percentages Lie: Rethinking Omega‑6 (LA & AA) Risk Biomarkers and Endocannabinoid Substrates The blind spot in fatty acid epidemiology Since the 1960s, most circulating fatty acid data have been reported as “percent of total” rather than as abs […]

Stefan Broselid wrote a new post

Mon, 17 Nov 2025 15:48:40 +0000

The Swedish Sin: When Evidence-Based Medicine Meets Bureaucratic Barriers The Swedish Sin Here’s a thing that’s been bothering me for months now. Sweden claims to have medical cannabis. We tell patients it’s “legal.” We point to […]

Stefan Broselid wrote a new post

Wed, 05 Nov 2025 17:33:04 +0000

How Diet and Exercise Modulate the Endocannabinoid System New Evidence for the Substrate-Driven Model I came across a fascinating recent study […]

Stefan Broselid wrote a new post

Wed, 29 Oct 2025 05:45:17 +0000

Lipidomic Markers Predict Autism Through ECS Dysfunction Autism research has long struggled with a fundamental question: why do so many disparate findings (maternal nutrition, inflammation, mitochondrial […]

Stefan Broselid wrote a new post

Thu, 23 Oct 2025 11:44:19 +0000

The Biochemical Plateau: Rethinking Linoleic Acid and Heart Health The Linoleic Acid Paradox: Protection or Peril? For decades, linoleic acid has enjoyed a privileged place in nutritional policy. It is the cornerstone of […]

Stefan Broselid wrote a new post

Sun, 19 Oct 2025 17:01:42 +0000

The Enzyme Inhibitor Paradox: Why Anti-Obesity Drugs Keep Failing A new study just proved something remarkable: researchers found a way to slash insulin levels by 53% in just two hours. Food intake dropped 23%. Body weight […]

Stefan Broselid wrote a new post

Wed, 08 Oct 2025 09:36:38 +0000

Beyond the ECS: Why you absolutely need a balanced diet Your body produces its own cannabis-like molecules. Right now, as you read this, your cells are manufacturing compounds that interact with the same receptors […]

Stefan Broselid wrote a new post

Tue, 30 Sep 2025 13:54:43 +0000

Let’s Start Asking the Uncomfortable Questions about the ECS A half-century of medical curricula has overlooked one of human physiology’s master regulators—the endocannabinoid system (ECS). But the conversation is s […]

Stefan Broselid wrote a new post

Fri, 19 Sep 2025 14:03:54 +0000

Soybean oil, linoleic acid, and the gut ECS A recent study titled ‘Diet high in linoleic acid dysregulates the intestinal endocannabinoid system and increases susceptibility to colitis in Mice’ shows […]

Stefan Broselid wrote a new post

Thu, 11 Sep 2025 12:57:48 +0000

The Emperor’s New Pathways: Endocannabinoids on the Arachidonic Acid Map Most NAFLD/MASLD reviews draw a neat AA trident—COX, LOX, CYP—while omitting the endocannabinoid system, even though AEA and 2‑AG are made on demand by NAPE‑ […]

Stefan Broselid wrote a new post

Fri, 29 Aug 2025 12:59:16 +0000

From Preprint to Peer Review: ECS.education Paper Accepted in IJCMCS The ECS.education community has a milestone to celebrate: our manuscript, “Bridging the gap: Integrating the endocannabinoid system into medical e […]

Stefan Broselid wrote a new post

Tue, 19 Aug 2025 09:03:16 +0000

How Scientific Tunnel Vision in Inflammation Research Ignores the Endocannabinoid System (ECS) When scientific tunnel vision becomes institutional blindness Lessons from history’s scientific blind spots Science has a troubling habit of missing t […]

Stefan Broselid wrote a new post

Sat, 02 Aug 2025 13:27:51 +0000

Obesity's metabolic fingerprint is characterised by ECS Dysfunction! Think of your body as a living journal, where each entry is made up of the molecules you absorb and the energy you store. Although obesity is often d […]

Stefan Broselid started the topic Alcohol Acutely Reduces 2-AG levels in the forum Infographics and educational content

Mon, 28 Jul 2025 13:06:37 +0000

Stefan Broselid wrote a new post

Wed, 23 Jul 2025 08:50:07 +0000

Maternal Obesity Disrupts Breast Milk PUFA Balance: New Insights into ECS Programming for Infants Let’s dive right in. In my earlier posts on ECS.education, we’ve talked about how maternal adiposity shapes breast milk’s endocannabinoid system (ECS) and […]

Stefan Broselid wrote a new post

Wed, 23 Jul 2025 05:03:47 +0000

The Endocannabinoid System: Dietary Precursor-Driven ECS & Medical Education Gap The Misunderstood Master Regulator The endocannabinoid system (ECS) is often considered the “cannabis system,” but this label ignores its true—and far b […]

Stefan Broselid wrote a new post

Sat, 19 Jul 2025 15:16:53 +0000

Beyond the Buzz: Cannabis Heart Risks vs. Diet-Driven ECS Overload Introduction: Beyond the Buzz – A Flawed Focus on Cannabis Recent headlines have lit up with warnings about cannabis and heart health, fueled by a sys […]

Stefan Broselid started the topic CNR1 expression During Lifespan in the forum Infographics and educational content

Fri, 11 Jul 2025 07:58:36 +0000

https://ecs.education/wp-content/uploads/2025/07/CNR1Lifespan-scaled.jpg

Stefan Broselid wrote a new post

Mon, 07 Jul 2025 14:09:20 +0000

An Update on Endogenous 2-AG Signaling: New Mechanisms and Cellular Integration Introduction: The Evolution of an Idea When I first began my career in molecular pharmacology, the endocannabinoid system (ECS) quickly became a sourc […]

Stefan Broselid wrote a new post

Tue, 17 Jun 2025 12:09:24 +0000

Obesity Rewires Your Endocannabinoid System (ECS): How Fat, Liver, Heart & Brain Are Transformed When we talk about obesity, most people focus on excess fat. But a closer look at the science—and the figure below—reveals a deeper story: obesity is a dis […]

Stefan Broselid wrote a new post

Wed, 04 Jun 2025 14:19:45 +0000

Paracetamol Confirmed as a Direct Analgesic DAGL Inhibitor: New Preprint Evidence Important Note: This blog post discusses findings from a recent scientific preprint, meaning the research has not yet been formally peer-reviewed. Preprints […]

Stefan Broselid wrote a new post

Fri, 23 May 2025 13:55:53 +0000

The Adiposity Filter: How Maternal Body Fat Reshapes Milk PUFAs for Your Baby's ECS At ECS.education, we’ve previously delved into how maternal metabolism and milk composition program infant development, the profound impact of maternal d […]

Stefan Broselid wrote a new post

Thu, 22 May 2025 15:34:00 +0000

The Agmatine-ECS-ASD Connection: New Hope for ASD by Boosting 2-AG and Calming the Brain The quest to understand and treat complex brain disorders has led researchers down many paths. Now, an often-overlooked endogenous molecule, agmatine, is s […]

Stefan Broselid wrote a new post

Mon, 19 May 2025 12:09:44 +0000

Acetaminophen (APAP) & the ECS: A Surprising New Twist in How Tylenol Really Works In a previous post, “Paracetamol: The Endocannabinoid System Connection,” we delved into the intriguing ways acetaminophen (paracetamol) interfaces with o […]

Stefan Broselid wrote a new post

Tue, 06 May 2025 14:15:37 +0000

Seeing is Believing: New Tech Reveals How The Endocannabinoid System Works in Real-Time For decades, scientists have known our bodies have an “inner cannabis system” – the endocannabinoid system (ECS). It’s a master regulator involved in eve […]

Stefan Broselid wrote a new post

Mon, 05 May 2025 12:52:34 +0000

Too Much Omega-6? New Link Shows Linoleic Acid Directly Flips a Master Metabolic Switch Our bodies have intricate systems for sensing the nutrients we eat. A key player is a protein complex called mTORC1, which acts like a master switch inside […]

Stefan Broselid wrote a new post

Fri, 02 May 2025 11:42:18 +0000

Maternal Obesity Reshapes Breast Milk's Endocannabinoid Landscape – A Missing Link in Metabolic Inheritance A growing body of research has established that the endocannabinoid system (ECS) is dysregulated in obesity. In both human and animal studies, obesity is […]